Building on over 40 years of light scattering research and development, ASTRA 7 includes an unrivaled range of analysis features.
ASTRA takes full advantage of modern multicore computers, processing data at blazing speeds and with superior accuracy.
Molar Mass Determination
Determine molar mass and size.
Molar Mass via Light Scattering
Light scattering stands alone in its ability to measure the molar mass of macromolecules in solution both accurately and quickly.
Molar Mass via Conventional and Universal Calibration
Build a bridge between legacy conventional and universal calibration results and modern, accurate light scattering analysis.
Protein Conjugate and Copolymer Analysis
Determine molar mass, size, and relative fractions.
If you have an RI detector, a UV detector, and a light scattering instrument, you can directly measure the molar mass, size, and relative
fractions of copolymers and protein conjugates.
Particles and Number Density
Determine size and number density with just a light scattering detector.
It is possible to measure the size and number density of a sample with just a light scattering instrument. ASTRA supports several sophisticated
models to determine the size of a macromolecule based solely on the angular variation in the light scattering intensity.
Translational Diffusion and Hydrodynamic Radius
Determine translational diffusion and hydrodynamic radius with dynamic light scattering.
With the support of a QELS instrument module, you can extend your data analysis to determine the translational diffusion and corresponding
hydrodynamic radius of your samples.
QELS batch Regularization and Cumulants
Determine translational diffusion and corresponding hydrodynamic radius of your unfractionated samples.
Measure viscosity directly using the Wyatt ViscoStar II.
ASTRA provides several analysis features that take advantage of viscosity data. Use these features to further quantify your macromolecules
to determine Mark-Houwink-Sakurada terms, hydrodynamic radius, and more.
Assess the shape of your molecules.
The shape of molecules can be assessed from the molar mass and rms radius of the sample.
Determine polymer branching from light scattering, viscosity, or both.
ASTRA includes sophisticated branching calculations to assess the branching characteristics of a polymer sample.
Evaluate the distribution of components in a sample.
Sample properties are determined for individual peaks in a chromatography run. ASTRA also supports visualizing these data in terms of the
distribution of these measured quantities. This is extremely powerful when assessing how much of a sample falls with a particular range of molar
mass or size. Learn more…
Second Virial Coefficient (A2) Measurements
Determine macromolecule self-association behavior.
The second virial coefficient (A2) is a measure of macromolecular self-association, and is one of the few parameters that
can be used to predict the crystallization properties of a sample. ASTRA allows you to measure this important characteristic.
dn/dc and UV extinction coefficient determination
Measure the dn/dc and UV extinction coefficients for your novel samples.
While dn/dc and UV extinction coefficients are documented for many existing compounds, they must be experimentally determined for
novel samples. ASTRA provides analysis features to measure these critical sample characteristics.
Band Broadening Correction
Model and account for inter-detector mixing effects.
While most analysis packages force you to live with the undesirable effects of passing a sample through a series of detectors. ASTRA's
revolutionary band broadening correction accounts for these effects to give you most accurate results possible.
Account for samples that absorb light.
If a sample absorbs light at the MALS laser wavelength, molar mass calculations will be skewed due to less light reaching the scattering volume
than expected. ASTRA uses the Forward Monitor detector signal available in all Wyatt MALS instruments to calculate the laser attenuation produced
by sample absorption and correct the scattering signal levels. In this manner accurate molecular weights are ensured, even in the presence of
Flatten out complicated FFF runs.
Certain analysis techniques, such as FFF, cause large changes in refractive index and viscosity measurements as flow rates are modified during
the run. This can make it difficult to properly analyze the file, as the RI and viscosity changes due to flow and pressure changes mask those
caused by the sample. ASTRA provides a mechanism to subtract a data collection run without sample (a 'blank') from a sample run to
reveal the sample-specific signal changes.
ASTRA provides a rock-solid scientific foundation for your results.
Wyatt Technology software is written by scientists for scientists. ASTRA was designed from the ground up to properly compute and propagate
uncertainties to ensure our results are publication-quality.
Cutting Edge Technology
Take advantage of Wyatt Technology's patented technologies.
Wyatt Technology is committed to pushing macromolecular characterization to new levels. Consequently, we have a very strong program to
develop intellectual property. Many of the algorithms in ASTRA are on the cutting edge of scientific analysis, and are either patented or have
patents pending. ASTRA is protected by:
- U.S. patent numbers: 5,528,366; 6,411,383; 6,651,009; 6,774,994; 7,386,427; 7,911,594;
- German patent Numbers: 694 33 615.7-08; 603 19 078.2-08;
- British patents based on European application numbers: EP 0 665 433; EP 1 510 807;
- Japanese patent Numbers: 3,580,380; 4,439,211; 4,381,914;
and other patents pending.