Wyatt Technology

Live Webinars

Characterization of Polymeric Excipients with Size Exclusion Chromatography and Light Scattering

Join us for a webinar on September 21 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

Polymeric and other content can contribute up to 90% of the total mass in a pharmaceutical product, where excipients play a critical role in the drug’s performance. In just one example of the importance of excipient properties for therapeutic effect, the molar mass and degree of branching in polymeric excipients directly impact the rate of drug release.
In this webinar we show how conventional characterization techniques including size exclusion chromatography (SEC) and bulk viscosity measurements may fall short. The addition of light scattering analysis provides complete characterization of molar mass, viscosity, branching, conformation, conjugation, and size of excipients and other polymers.

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Novel Ways of Screening Colloidal Nanoparticles Under Preclinical-Relevant Conditions

Join us for a webinar on October 3 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

Colloidal nanoparticles have shown tremendous potential as cancer drug carriers and as phototherapeutics. However, screening the stability of nanoparticles under physiological and phototherapeutic conditions is a major challenge which needs to be addressed in order to ensure a successful clinical translation.
The design, development and implementation of unique programmatic screens using a high-throughput dynamic light scattering (HT-DLS) plate reader are described herein for automated hydrodynamic size measurements of colloidal nanoparticles. The data obtained from such measurements provide clinically-relevant particle size distribution assessments that are directly related to the stability and aggregation profiles of the nanoparticles under putative physiological and phototherapeutic conditions. Notably, those profiles are dependent not only on the size and surface coating of the nanoparticles, but also on their composition.

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For essential macromolecular and nanoparticle characterization—The Solution is Light™

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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